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Blue light-filtering intraocular lens may inhibit onset, progression of age-related macular degeneration. Invest Ophthalmol Vis Sci. 50(10):4777-4785.

March 19, 2010

Implantation of a blue light-filtering intraocular lens (IOL) may prevent or delay the development of age-related macular degeneration, according to a study.

In a prospective, randomized study of 42 patients; 21 patients were implanted with an AcrySof Natural IOL (Alcon) and 21 patients received an AcrySof three-piece acrylic IOL (Alcon). The AcrySof Natural has blue light-filtering capability. Mean patient age was 74 years in the AcrySof Natural group and 71 years in the AcrySof group.

Investigators measured macular pigment optical density 1 week before surgery, 1 week after surgery, and 3, 6 and 12 months after surgery. Serum concentrations of the carotenoids lutein and zeaxanthin were also assessed at each follow-up visit.

Results revealed that average macular pigment optical density across the retina was significantly increased at 3 months in the AcrySof Natural group; macular pigment optical density was stable in the AcrySof group. Results showed that implantation of a blue light-filtering IOL increased macular pigment optical density in the absence of raised lutein and zeaxanthin serum levels.

Authors noted: "However, further study is required in the form of controlled long-term trials to investigate whether implantation of a blue light-filtering IOL is effective in preventing or delaying development or progression of AMD.

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Our Bay Area office, located at 15251 National Ave, Suite 100, Los Gatos, CA 95032, provides eyecare, eye exam, LASIK, laser vision correction, cataract and other eye surgeries for patients in the following areas: Bay Area Eye Doctor, Campbell, Cupertino, Fremont, Gilroy, Los Altos, Los Altos Hills, Los Gatos Eye Care, Milpitas, Morgan Hill, Monte Sereno, Mountain View, Palo Alto, Pleasanton, San Jose, San Martin, San Mateo, Santa Clara County, Santa Clara Valley, Saratoga, Scotts Valley, South Bay, Sunnyvale